KUPO_0000005
type: Class
subclass of: KUPO_0000004
alternative label: In vivo model

Axiom
annotated target: In vivo model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: KUPO_0000005
annotated property: altLabel

Polycystic kidney disease
type: Class

Genetic model
type: Class
subclass of: KUPO_0000005

Spontaneous genetic trait model
type: Class
subclass of: Genetic model

Transgenic model
type: Class
subclass of: Genetic model

Knock-out model
type: Class
subclass of: Genetic model

Surgical model
type: Class
subclass of: KUPO_0000005

Renal ablation model
type: Class
subclass of: Surgical model
alternative label: Nephrectomy model

Axiom
annotated target: Nephrectomy model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Renal ablation model
annotated property: altLabel

Agent-induced model
type: Class
subclass of: KUPO_0000005

Metabolic model of nephropathy
type: Class
subclass of: KUPO_0000005

Diabetic nephropathy model
type: Class
subclass of: Metabolic model of nephropathy
subclass of: Restriction
  on property: mimics
  some values from: DOID 2370

Type 1 diabetes associated diabetic nephropathy model
type: Class
subclass of: Diabetic nephropathy model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100001

Streptozotocin-induced model of diabetic nephropathy
type: Class
subclass of: Agent-induced model
subclass of: Type 1 diabetes associated diabetic nephropathy model
alternative label: STZ
alternative label: STZ-induced diabetic nephropathy
comment: Streptozotocin (STZ) is an analogue of N-acetylglucosamine (GlcNAc). It is readily transported into pancreatic beta-cells by GLUT-2 and selectively inhibits the activity of beta-cell O-GlcNAcase, which is responsible for removing O-GlcNAc from protein. This causes irreversible O-glycosylation of intracellular proteins and results in beta-cell apoptosis. STZ can be used to study diabetic nephropathy in most rodent strains. However the severity of injury is dependent on genetic background. Moreover, GLUT-2 is also expressed by renal and hepatic cells. The cytotoxicity of STZ is thus not restricted to pancreatic beta-cells but also affects kidney and liver cells.
alternative label: diabetic nephropathy induced by STZ
alternative label: diabetic nephropathy induced by streptozotocin

Axiom
annotated target: STZ-induced diabetic nephropathy
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Streptozotocin (STZ) is an analogue of N-acetylglucosamine (GlcNAc). It is readily transported into pancreatic beta-cells by GLUT-2 and selectively inhibits the activity of beta-cell O-GlcNAcase, which is responsible for removing O-GlcNAc from protein. This causes irreversible O-glycosylation of intracellular proteins and results in beta-cell apoptosis. STZ can be used to study diabetic nephropathy in most rodent strains. However the severity of injury is dependent on genetic background. Moreover, GLUT-2 is also expressed by renal and hepatic cells. The cytotoxicity of STZ is thus not restricted to pancreatic beta-cells but also affects kidney and liver cells.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy
annotated property: comment

Axiom
annotated target: diabetic nephropathy induced by streptozotocin
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: STZ
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: diabetic nephropathy induced by STZ
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Streptozotocin-induced mouse model of diabetic nephropathy
type: Class
subclass of: Streptozotocin-induced model of diabetic nephropathy

Low dose streptozotocin-induced model of diabetic nephropathy
type: Class
subclass of: Streptozotocin-induced mouse model of diabetic nephropathy
comment: Multiple low-dose injection of STZ (50-55mg/kg for 5 consecutive days, i.p.). C57BLKS and DBA2/J mouse strains are more susceptible to low-dose STZ-induced diabetic nephropathy compared to C57Bl/6, FVB/N, A/J, BALB/C or Swiss Webster genetic backgrounds.
alternative label: low STZ
alternative label: low streptozotocin
alternative label: low-dose STZ
alternative label: low-dose mouse model of diabetic nephropathy
alternative label: low-dose streptozotocin

Axiom
annotated target: Multiple low-dose injection of STZ (50-55mg/kg for 5 consecutive days, i.p.). C57BLKS and DBA2/J mouse strains are more susceptible to low-dose STZ-induced diabetic nephropathy compared to C57Bl/6, FVB/N, A/J, BALB/C or Swiss Webster genetic backgrounds.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy
annotated property: comment

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: low STZ
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: low-dose STZ
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: low-dose mouse model of diabetic nephropathy
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: low-dose streptozotocin
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: low streptozotocin
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

High dose streptozotocin-induced model of diabetic nephropathy
type: Class
subclass of: Streptozotocin-induced mouse model of diabetic nephropathy
comment: Single high-dose injection of STZ (>= 200mg/kg, i.p.) or two-dose regimen (2x100-125mg/kg for 2 consecutive days, i.p.).
alternative label: high STZ
alternative label: high streptozotocin
alternative label: high-dose STZ
alternative label: high-dose mouse model of diabetic nephropathy
alternative label: high-dose streptozotocin

Axiom
annotated target: high-dose mouse model of diabetic nephropathy
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: high streptozotocin
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: high-dose streptozotocin
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Single high-dose injection of STZ (>= 200mg/kg, i.p.) or two-dose regimen (2x100-125mg/kg for 2 consecutive days, i.p.).
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy
annotated property: comment

Axiom
annotated target: high STZ
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: high-dose STZ
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy
annotated property: altLabel

Streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
type: Class
subclass of: Knock-out model
subclass of: Streptozotocin-induced model of diabetic nephropathy
comment: Decreased eNOS activity is associated with the development of advanced nephropathy in patients with type 1 and type 2 diabetes.
alternative label: STZ-eNOS(-/-)

Axiom
annotated target: STZ-eNOS(-/-)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
annotated property: altLabel

Axiom
annotated target: Decreased eNOS activity is associated with the development of advanced nephropathy in patients with type 1 and type 2 diabetes.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
annotated property: comment

Low dose streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
type: Class
subclass of: Low dose streptozotocin-induced model of diabetic nephropathy
subclass of: Streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
comment: This model has been developed in the nephropathy resistant C57Bl/6 background. Compared with diabetic WT mice, low dose-STZ eNOS(-/-) mice develop more severe albuminuria, mesangial expansion, mesangiolysis and focal sclerosis.

Axiom
annotated target: This model has been developed in the nephropathy resistant C57Bl/6 background. Compared with diabetic WT mice, low dose-STZ eNOS(-/-) mice develop more severe albuminuria, mesangial expansion, mesangiolysis and focal sclerosis.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Low dose streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
annotated property: comment

High dose streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
type: Class
subclass of: High dose streptozotocin-induced model of diabetic nephropathy
subclass of: Streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
comment: This model has been developed in the nephropathy resistant C57Bl/6 background. Compared with diabetic WT mice, high dose-STZ eNOS(-/-) mice develop more severe albuminuria, mesangial expansion, mesangiolysis and focal sclerosis. Diabetic knock-out mice also exhibit robust glomerulosclerosis and tubulointerstitial injury, and significant hypertension and mortality.

Axiom
annotated target: This model has been developed in the nephropathy resistant C57Bl/6 background. Compared with diabetic WT mice, high dose-STZ eNOS(-/-) mice develop more severe albuminuria, mesangial expansion, mesangiolysis and focal sclerosis. Diabetic knock-out mice also exhibit robust glomerulosclerosis and tubulointerstitial injury, and significant hypertension and mortality.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: High dose streptozotocin-induced model of diabetic nephropathy associated with eNOS deletion
annotated property: comment

Streptozotocin-induced rat model of diabetic nephropathy
type: Class
subclass of: Streptozotocin-induced model of diabetic nephropathy
comment: STZ-induced diabetic nephropathy is commonly studied in Sprague-Dawley (SD), Wistar-Kyoto (WKY), or spontaneously hypertensive (SHR) rats (SD=55mg/kg, WKY=60mg/kg, SHR=45mg/kg, one injection, i.v.).

Axiom
annotated target: STZ-induced diabetic nephropathy is commonly studied in Sprague-Dawley (SD), Wistar-Kyoto (WKY), or spontaneously hypertensive (SHR) rats (SD=55mg/kg, WKY=60mg/kg, SHR=45mg/kg, one injection, i.v.).
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced rat model of diabetic nephropathy
annotated property: comment

Streptozotocin-induced rat model of diabetic nephropathy associated with uninephrectomy
type: Class
subclass of: Renal ablation model
subclass of: Streptozotocin-induced rat model of diabetic nephropathy
comment: Uninephrectomy is thought to accelerate the progression of renal injury. However, interpretation of this model is complex as it is difficult to dissociate the relative contribution of STZ-induced hyperglycemia and uninephrectomy-induced changes in the development of glomerular lesions.

Axiom
annotated target: Uninephrectomy is thought to accelerate the progression of renal injury. However, interpretation of this model is complex as it is difficult to dissociate the relative contribution of STZ-induced hyperglycemia and uninephrectomy-induced changes in the development of glomerular lesions.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Streptozotocin-induced rat model of diabetic nephropathy associated with uninephrectomy
annotated property: comment

Akita model of diabetic nephropathy
type: Class
subclass of: Spontaneous genetic trait model
subclass of: Type 1 diabetes associated diabetic nephropathy model
comment: Autosomal dominant mutation, generally studied in heterozygous state. Lead to impaired beta cell function and survival due to insulin misfolding and endoplasmic reticular stress. DBA2/J mouse strain is more susceptible to Akita mutation compared to C57Bl/6 and FVB/N genetic backgrounds.
alternative label: Ins2(Akita/+)
alternative label: Ins2Akita

Axiom
annotated target: Ins2Akita
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Akita model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Ins2(Akita/+)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Akita model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Autosomal dominant mutation, generally studied in heterozygous state. Lead to impaired beta cell function and survival due to insulin misfolding and endoplasmic reticular stress. DBA2/J mouse strain is more susceptible to Akita mutation compared to C57Bl/6 and FVB/N genetic backgrounds.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Akita model of diabetic nephropathy
annotated property: comment

Akita model of diabetic nephropathy associated with eNOS deletion
type: Class
subclass of: Knock-out model
subclass of: Akita model of diabetic nephropathy
comment: Decreased eNOS activity is associated with the development of advanced nephropathy in patients with type 1 and type 2 diabetes.
alternative label: eNOS(-/-)Ins2(Akita/+)

Axiom
annotated target: Decreased eNOS activity is associated with the development of advanced nephropathy in patients with type 1 and type 2 diabetes.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Akita model of diabetic nephropathy associated with eNOS deletion
annotated property: comment

Axiom
annotated target: eNOS(-/-)Ins2(Akita/+)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Akita model of diabetic nephropathy associated with eNOS deletion
annotated property: altLabel

FVB-OVE26
type: Class
subclass of: Transgenic model
subclass of: Type 1 diabetes associated diabetic nephropathy model
alternative label: CaMTg
alternative label: FVB(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ
alternative label: OVE26
comment: Transgenic model of early-onset type 1 diabetes. Generated in FVB/N background. The calmodulin gene is under the control of a rat insulin 2 promoter. Calmodulin is thus specifically overexpressed in the beta cells and exerts beta-cell toxicity. CaMTg mice develop persistent proteinuria, tubulointerstital fibrosis, glomerualr basement thickening and a considerable increase in the glomerular and mesangial areas. Moreover, these mice exhibit most of the pathologic hallmarks of human diabetic nephropathy, that is mesangiolysis, Kimmelstiel-Wilson-like nodular lesions, exudative lesions and arteriolar hyalinosis.

Axiom
annotated target: FVB(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: FVB-OVE26
annotated property: altLabel

Axiom
annotated target: CaMTg
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: FVB-OVE26
annotated property: altLabel

Axiom
annotated target: OVE26
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: FVB-OVE26
annotated property: altLabel

Axiom
annotated target: Transgenic model of early-onset type 1 diabetes. Generated in FVB/N background. The calmodulin gene is under the control of a rat insulin 2 promoter. Calmodulin is thus specifically overexpressed in the beta cells and exerts beta-cell toxicity. CaMTg mice develop persistent proteinuria, tubulointerstital fibrosis, glomerualr basement thickening and a considerable increase in the glomerular and mesangial areas. Moreover, these mice exhibit most of the pathologic hallmarks of human diabetic nephropathy, that is mesangiolysis, Kimmelstiel-Wilson-like nodular lesions, exudative lesions and arteriolar hyalinosis.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: FVB-OVE26
annotated property: comment

NOD model of diabetic nephropathy
type: Class
subclass of: Spontaneous genetic trait model
subclass of: Type 1 diabetes associated diabetic nephropathy model
alternative label: Non Obese Diabetic mice
comment: The susceptibility to type 1 diabetes in NOD mice is polygenic and strongly depends on environment. Diabetes develop as a result of leukocytic infiltrate of pancreatic islet (auto-immune disease). However, the onset of diabetes is very variable, as the incidence of spontaneous diabetes in the NOD mouse is 60-80% in females, but dramatically lower in males (20-30%). Female NOD mice exhibit increased glomerular area, glomerulosclerosis and glomerular basal membrane thickness at 50 weeks of age.

Axiom
annotated target: The susceptibility to type 1 diabetes in NOD mice is polygenic and strongly depends on environment. Diabetes develop as a result of leukocytic infiltrate of pancreatic islet (auto-immune disease). However, the onset of diabetes is very variable, as the incidence of spontaneous diabetes in the NOD mouse is 60-80% in females, but dramatically lower in males (20-30%). Female NOD mice exhibit increased glomerular area, glomerulosclerosis and glomerular basal membrane thickness at 50 weeks of age.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: NOD model of diabetic nephropathy
annotated property: comment

Axiom
annotated target: Non Obese Diabetic mice
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: NOD model of diabetic nephropathy
annotated property: altLabel

Type 2 diabetes associated diabetic nephropathy model
type: Class
subclass of: Diabetic nephropathy model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100002

db/db model of diabetic nephropathy
type: Class
subclass of: Spontaneous genetic trait model
subclass of: Type 2 diabetes associated diabetic nephropathy model
comment: C57BKS(db/db) is one of the best model of nephropathy associated with type 2 diabetes. The db/db mouse, resulting from a mutation in the leptin receptor gene (Lpr), develops hyperglycaemia, glomerular hypertrophy, and sclerosis with age but is not associated with lesions of tubulointerstitial fibrosis. Mutations of the leptin receptor are however a rare cause of type 2 diabetes in humans, and the direct relevance to the human condition may thus be argued.
alternative label: Lpr(db/db)
alternative label: db/db

Axiom
annotated target: db/db
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: db/db model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: C57BKS(db/db) is one of the best model of nephropathy associated with type 2 diabetes. The db/db mouse, resulting from a mutation in the leptin receptor gene (Lpr), develops hyperglycaemia, glomerular hypertrophy, and sclerosis with age but is not associated with lesions of tubulointerstitial fibrosis. Mutations of the leptin receptor are however a rare cause of type 2 diabetes in humans, and the direct relevance to the human condition may thus be argued.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: db/db model of diabetic nephropathy
annotated property: comment

Axiom
annotated target: Lpr(db/db)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: db/db model of diabetic nephropathy
annotated property: altLabel

db/db model of diabetic nephropathy associated wih eNOS deletion
type: Class
subclass of: Knock-out model
subclass of: db/db model of diabetic nephropathy
comment: Decreased eNOS activity is associated with the development of advanced nephropathy in patients with type 1 and type 2 diabetes. This model has been developed in C57BLKS background. Compared to eNOS(+/+) mice, eNOS(-/-) mice exhibit greater mesangial expansion, glomerular basement membrane thickening, arteriolar hyalinosis, mesangiolysis, nodular glomerulosclerosis and tubulointerstitial injury.
alternative label: Lpr(db/db)eNOS(-/-)

Axiom
annotated target: Lpr(db/db)eNOS(-/-)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: db/db model of diabetic nephropathy associated wih eNOS deletion
annotated property: altLabel

Axiom
annotated target: Decreased eNOS activity is associated with the development of advanced nephropathy in patients with type 1 and type 2 diabetes. This model has been developed in C57BLKS background. Compared to eNOS(+/+) mice, eNOS(-/-) mice exhibit greater mesangial expansion, glomerular basement membrane thickening, arteriolar hyalinosis, mesangiolysis, nodular glomerulosclerosis and tubulointerstitial injury.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: db/db model of diabetic nephropathy associated wih eNOS deletion
annotated property: comment

Zucker model of diabetic nephropathy
type: Class
subclass of: Spontaneous genetic trait model
subclass of: Type 2 diabetes associated diabetic nephropathy model
alternative label: Lpr(fa/fa)
alternative label: Obese Zucker Diabetic Fatty
comment: Obese Zucker Diabetic Fatty (ZDF) rats are homozygotes for a mutation in the leptin receptor gene (Lpr), thus reducing the affinity of the leptin receptor for its ligand. Male obese ZDF rats are glucose-intolerant, transiently hyperinsulinemic, hyperlipidemic, hyperleptinemic and develop mild nephropathy. Female obese ZDF rats do not express the diabetic phenotype only on diabetogenic diet, not on regular chow diet. Lean ZDF rats, whether male or female do not express the diabetic phenotype.
alternative label: ZDF
alternative label: fa/fa

Axiom
annotated target: ZDF
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Zucker model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Obese Zucker Diabetic Fatty
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Zucker model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Lpr(fa/fa)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Zucker model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: Obese Zucker Diabetic Fatty (ZDF) rats are homozygotes for a mutation in the leptin receptor gene (Lpr), thus reducing the affinity of the leptin receptor for its ligand. Male obese ZDF rats are glucose-intolerant, transiently hyperinsulinemic, hyperlipidemic, hyperleptinemic and develop mild nephropathy. Female obese ZDF rats do not express the diabetic phenotype only on diabetogenic diet, not on regular chow diet. Lean ZDF rats, whether male or female do not express the diabetic phenotype.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Zucker model of diabetic nephropathy
annotated property: comment

Axiom
annotated target: fa/fa
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Zucker model of diabetic nephropathy
annotated property: altLabel

NONcNZO10/LtJ model of diabetic nephropathy
type: Class
subclass of: Genetic model
subclass of: Type 2 diabetes associated diabetic nephropathy model
alternative label: NONcNZO10/LtJ
comment: NONcNZO10/LtJ is an inbred congenic strain derived from cross between the NonObese Nondiabetic (NON/LtJ) strain and the New Zealand Obese (NZO/HlLt) strain. These mice have been developed as a polygenic model of obesity-induced type 2 diabetes and metabolic syndrome. The obesity is more moderate than in the db/db strain.

Axiom
annotated target: NONcNZO10/LtJ
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: NONcNZO10/LtJ model of diabetic nephropathy
annotated property: altLabel

Axiom
annotated target: NONcNZO10/LtJ is an inbred congenic strain derived from cross between the NonObese Nondiabetic (NON/LtJ) strain and the New Zealand Obese (NZO/HlLt) strain. These mice have been developed as a polygenic model of obesity-induced type 2 diabetes and metabolic syndrome. The obesity is more moderate than in the db/db strain.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: NONcNZO10/LtJ model of diabetic nephropathy
annotated property: comment

KKAy model of diabetic nephropathy
type: Class
subclass of: Transgenic model
subclass of: Type 2 diabetes associated diabetic nephropathy model
alternative label: KK-Ay
comment: The KKAy mouse is a congenital strain established by transduction of yellow obese gene (Ay) into the KK mice. The inbred KK mice develops type 2 diabetes with moderate obesity and hyperglycemia. The introduction of the Ay allele causes massive obesity and overt type 2 diabetes with elevated plasma glucose and insulin resistance. Furthermore, KKAy mice exhibits albuminuria, mesangial expansion, glomerulosclerosis and glomerular capillary basement thickening.

Axiom
annotated target: The KKAy mouse is a congenital strain established by transduction of yellow obese gene (Ay) into the KK mice. The inbred KK mice develops type 2 diabetes with moderate obesity and hyperglycemia. The introduction of the Ay allele causes massive obesity and overt type 2 diabetes with elevated plasma glucose and insulin resistance. Furthermore, KKAy mice exhibits albuminuria, mesangial expansion, glomerulosclerosis and glomerular capillary basement thickening.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: KKAy model of diabetic nephropathy
annotated property: comment

Axiom
annotated target: KK-Ay
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: KKAy model of diabetic nephropathy
annotated property: altLabel

Ureteral obstruction model
type: Class
subclass of: KUPO_0000005
subclass of: Surgical model
subclass of: Restriction
  on property: mimics
  some values from: DOID 5199
alternative label: Obstructive nephropathy

Axiom
annotated target: Obstructive nephropathy
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Ureteral obstruction model
annotated property: altLabel

Ureteral obstruction model, Adult
type: Class
subclass of: Ureteral obstruction model

Partial ureteral obstruction model, Adult
type: Class
subclass of: Ureteral obstruction model, Adult

Partial unilateral ureteral obstruction model, Adult
type: Class
subclass of: Partial ureteral obstruction model, Adult

Partial bilateral ureteral obstruction model, Adult
type: Class
subclass of: Partial ureteral obstruction model, Adult

Complete ureteral obstruction model, Adult
type: Class
subclass of: Ureteral obstruction model, Adult

Complete unilateral obstruction model, Adult
type: Class
subclass of: Complete ureteral obstruction model, Adult

Complete bilateral obstruction model, Adult
type: Class
subclass of: Complete ureteral obstruction model, Adult

Ureteral obstruction model, Fetal
type: Class
subclass of: Ureteral obstruction model

Partial ureteral obstruction model, Fetal
type: Class
subclass of: Ureteral obstruction model, Fetal

Partial unilateral ureteral obstruction model, Fetal
type: Class
subclass of: Partial ureteral obstruction model, Fetal

Partial bilateral ureteral obstruction model, Fetal
type: Class
subclass of: Partial ureteral obstruction model, Fetal

Complete ureteral obstruction model, Fetal
type: Class
subclass of: Ureteral obstruction model, Fetal

Complete unilateral obstruction model, Fetal
type: Class
subclass of: Complete ureteral obstruction model, Fetal

Complete bilateral obstruction model, Fetal
type: Class
subclass of: Complete ureteral obstruction model, Fetal
comment: l

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: l
annotated source: Complete bilateral obstruction model, Fetal
annotated property: comment

Ureteral obstruction model, Neonatal
type: Class
subclass of: Ureteral obstruction model

Partial ureteral obstruction model, Neonatal
type: Class
subclass of: Ureteral obstruction model, Neonatal

Partial unilateral ureteral obstruction model, Neonatal
type: Class
subclass of: Partial ureteral obstruction model, Neonatal
alternative label: Neonatal PUUO Model
alternative label: Neonatal Partial UUO Model

Axiom
annotated target: Neonatal Partial UUO Model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Partial unilateral ureteral obstruction model, Neonatal
annotated property: altLabel

Axiom
annotated target: Neonatal PUUO Model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Partial unilateral ureteral obstruction model, Neonatal
annotated property: altLabel

Partial bilateral ureteral obstruction model, Neonatal
type: Class
subclass of: Partial ureteral obstruction model, Neonatal

Complete ureteral obstruction model, Neonatal
type: Class
subclass of: Ureteral obstruction model, Neonatal

Complete unilateral obstruction model, Neonatal
type: Class
subclass of: Complete ureteral obstruction model, Neonatal

Complete bilateral obstruction model, Neonatal
type: Class
subclass of: Complete ureteral obstruction model, Neonatal

Chronic renal failure model
type: Class
subclass of: KUPO_0000005
subclass of: Restriction
  on property: mimics
  some values from: DOID 784

Sub-total nephrectomy model
type: Class
subclass of: Chronic renal failure model
alternative label: 5/6 nephrectomy model
comment: Rather that mimicking a renal disease, sub-total nephrectomy models the progressive renal failure associated to loss of renal mass. The rate of progression to renal failure is closely related to the amount of tissue excised. It is thus necessary to weight and calculate the proportion of excised tissue to limit inter-individual variations.

Axiom
annotated target: 5/6 nephrectomy model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Sub-total nephrectomy model
annotated property: altLabel

Axiom
annotated target: Rather that mimicking a renal disease, sub-total nephrectomy models the progressive renal failure associated to loss of renal mass. The rate of progression to renal failure is closely related to the amount of tissue excised. It is thus necessary to weight and calculate the proportion of excised tissue to limit inter-individual variations.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Sub-total nephrectomy model
annotated property: comment

Sub-total nephrectomy ablation model
type: Class
subclass of: Renal ablation model
subclass of: Sub-total nephrectomy model
alternative label: Ablation model
comment: In this model, one kidney is removed (uninephrectomy) and blood flow is interrupted to the poles of the remaining kidney (ligation of polar branches of the renal artery). This ligation model is associated with severe hypertension.

Axiom
annotated target: In this model, one kidney is removed (uninephrectomy) and blood flow is interrupted to the poles of the remaining kidney (ligation of polar branches of the renal artery). This ligation model is associated with severe hypertension.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Sub-total nephrectomy ablation model
annotated property: comment

Axiom
annotated target: Ablation model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Sub-total nephrectomy ablation model
annotated property: altLabel

Sub-total nephrectomy ligation model
type: Class
subclass of: Sub-total nephrectomy model
comment: In this model, one kidney is removed and the 2 poles of the remaining kidney are removed 1-2 weeks later.
alternative label: Infarction model

Axiom
annotated target: Infarction model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Sub-total nephrectomy ligation model
annotated property: altLabel

Axiom
annotated target: In this model, one kidney is removed and the 2 poles of the remaining kidney are removed 1-2 weeks later.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Sub-total nephrectomy ligation model
annotated property: comment

Acute renal failure model
type: Class
subclass of: KUPO_0000005
subclass of: Restriction
  on property: mimics
  some values from: DOID 3021
alternative label: AKI: Acute kidney injury
alternative label: ARF
alternative label: Acute kidney injury model
alternative label: Acute renal failure

Axiom
annotated target: Acute kidney injury model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Acute renal failure model
annotated property: altLabel

Axiom
annotated target: AKI: Acute kidney injury
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Acute renal failure model
annotated property: altLabel

Axiom
annotated target: Acute renal failure
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Acute renal failure model
annotated property: altLabel

Axiom
annotated target: ARF
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Acute renal failure model
annotated property: altLabel

Ischemia/reperfusion injury model
type: Class
subclass of: KUPO_0000005
subclass of: Surgical model
subclass of: Acute renal failure model
alternative label: ATN
alternative label: Acute tubular necrosis model
alternative label: IARF
comment: Ischemia/reperfusion is the major cause of AKI in native and transplant kidneys. The consequences of ischemia/reperfusion are proportional to the period of ischemia, and depends on animal species and age.
alternative label: ischemic acute renal failure
alternative label: renal ischemia/reperfusion injury

Axiom
annotated target: Ischemia/reperfusion is the major cause of AKI in native and transplant kidneys. The consequences of ischemia/reperfusion are proportional to the period of ischemia, and depends on animal species and age.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Ischemia/reperfusion injury model
annotated property: comment

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: renal ischemia/reperfusion injury
annotated source: Ischemia/reperfusion injury model
annotated property: altLabel

Axiom
annotated target: Acute tubular necrosis model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Ischemia/reperfusion injury model
annotated property: altLabel

Axiom
annotated target: ATN
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Ischemia/reperfusion injury model
annotated property: altLabel

Axiom
created by: http://kupkb.org/populous#OPPL_pattern
annotated target: ischemic acute renal failure
annotated source: Ischemia/reperfusion injury model
annotated property: altLabel

Axiom
annotated target: IARF
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Ischemia/reperfusion injury model
annotated property: altLabel

Bilateral ischemia/reperfusion injury model
type: Class
subclass of: Ischemia/reperfusion injury model
comment: Bilateral clamping of the renal pedicele. Simulates AKI induced by severe acute hypotension.

Axiom
annotated target: Bilateral clamping of the renal pedicele. Simulates AKI induced by severe acute hypotension.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Bilateral ischemia/reperfusion injury model
annotated property: comment

Unilateral ischemia/reperfusion injury model
type: Class
subclass of: Ischemia/reperfusion injury model
comment: Unilateral clamping of the renal pedicele. Allows comparison with contralateral kidney and increases survival rate.

Axiom
annotated target: Unilateral clamping of the renal pedicele. Allows comparison with contralateral kidney and increases survival rate.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Unilateral ischemia/reperfusion injury model
annotated property: comment

Unilateral ischemia/reperfusion injury model associated with uninephrectomy
type: Class
subclass of: Renal ablation model
subclass of: Ischemia/reperfusion injury model
comment: Uninephrectomy is followed by unilateral clamping of the pedicele of the remaining kidney. More closely mimicks the situation occuring in renal transplantation.

Axiom
annotated target: Uninephrectomy is followed by unilateral clamping of the pedicele of the remaining kidney. More closely mimicks the situation occuring in renal transplantation.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Unilateral ischemia/reperfusion injury model associated with uninephrectomy
annotated property: comment

Nephrotoxic model
type: Class
subclass of: Agent-induced model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100003
comment: Kidneys are particularly prone to toxic damages, due to their ability to concentrate and metabolize chemicals. Molecules can be toxic for either renal vasculature, glomerular cells, and tubular epithelium. Most often, in animal models mimicking the nephrotoxic insults, single exposure results in acute renal disease with resolution and regeneration whereas repeat exposures induces progressive renal disease.

Axiom
annotated target: Kidneys are particularly prone to toxic damages, due to their ability to concentrate and metabolize chemicals. Molecules can be toxic for either renal vasculature, glomerular cells, and tubular epithelium. Most often, in animal models mimicking the nephrotoxic insults, single exposure results in acute renal disease with resolution and regeneration whereas repeat exposures induces progressive renal disease.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Nephrotoxic model
annotated property: comment

Podocyte-toxicity model
type: Class
subclass of: Nephrotoxic model

Focal segmental glomerulosclerosis model
type: Class
subclass of: KUPO_0000005
subclass of: Restriction
  on property: mimics
  some values from: DOID 1312
alternative label: FSGS

Axiom
annotated target: FSGS
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Focal segmental glomerulosclerosis model
annotated property: altLabel

Primary focal segmental glomerulosclerosis model
type: Class
subclass of: Podocyte-toxicity model
subclass of: Focal segmental glomerulosclerosis model
alternative label: Toxic model of focal segmental glomerulosclerosis
comment: Toxic models induce direct podocyte injury including podocyte oxidative stress, foot process effacement and glomerulosclerosis.

Axiom
annotated target: Toxic model of focal segmental glomerulosclerosis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Primary focal segmental glomerulosclerosis model
annotated property: altLabel

Axiom
annotated target: Toxic models induce direct podocyte injury including podocyte oxidative stress, foot process effacement and glomerulosclerosis.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Primary focal segmental glomerulosclerosis model
annotated property: comment

Secondary focal segmental glomerulosclerosis model
type: Class
subclass of: Renal ablation model
subclass of: Focal segmental glomerulosclerosis model
alternative label: Post adaptative focal segmental glomerulosclerosis
comment: Renal ablation models induce glomerular hypertension (elevated glomerular capillary pressures and flow rates) as a consequence of the reduced number of functioning nephrons or other glomerular stress. This adaptative response is considered as the cause of secondary podocyte injury

Axiom
annotated target: Renal ablation models induce glomerular hypertension (elevated glomerular capillary pressures and flow rates) as a consequence of the reduced number of functioning nephrons or other glomerular stress. This adaptative response is considered as the cause of secondary podocyte injury
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Secondary focal segmental glomerulosclerosis model
annotated property: comment

Axiom
annotated target: Post adaptative focal segmental glomerulosclerosis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Secondary focal segmental glomerulosclerosis model
annotated property: altLabel

Nephrotic syndrome model
type: Class
subclass of: Podocyte-toxicity model
subclass of: Restriction
  on property: mimics
  some values from: DOID 1184

Adriamycin-induced nephrotic syndrome model
type: Class
subclass of: Focal segmental glomerulosclerosis model
subclass of: Nephrotic syndrome model
comment: Adriamycin is an antibiotic with antineoplasic properties (DNA replication inhibition). Its use is associated with nephrotic syndrome in clinic. The principal site of action of adriamycin is the podocyte (foot process fusion).
alternative label: Adriamycin nephropathy
alternative label: Doxorubicin induced nephropathy

Axiom
annotated target: Adriamycin is an antibiotic with antineoplasic properties (DNA replication inhibition). Its use is associated with nephrotic syndrome in clinic. The principal site of action of adriamycin is the podocyte (foot process fusion).
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Adriamycin-induced nephrotic syndrome model
annotated property: comment

Axiom
annotated target: Doxorubicin induced nephropathy
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Adriamycin-induced nephrotic syndrome model
annotated property: altLabel

Axiom
annotated target: Adriamycin nephropathy
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Adriamycin-induced nephrotic syndrome model
annotated property: altLabel

Puromycin aminonucleoside-induced nephrotic syndrome model
type: Class
subclass of: Nephrotic syndrome model
comment: PAN is an antibiotic with antineoplasic properties. Its use is associated with nephrotic syndrome in clinic. The principal site of action of PAN is the podocyte (foot process fusion). Mice are not susceptible to PAN.
alternative label: PAN nephrosis
alternative label: PAN nephrotic syndrome

Axiom
annotated target: PAN is an antibiotic with antineoplasic properties. Its use is associated with nephrotic syndrome in clinic. The principal site of action of PAN is the podocyte (foot process fusion). Mice are not susceptible to PAN.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Puromycin aminonucleoside-induced nephrotic syndrome model
annotated property: comment

Axiom
annotated target: PAN nephrosis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Puromycin aminonucleoside-induced nephrotic syndrome model
annotated property: altLabel

Axiom
annotated target: PAN nephrotic syndrome
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Puromycin aminonucleoside-induced nephrotic syndrome model
annotated property: altLabel

Tubular-toxicity model
type: Class
subclass of: Nephrotoxic model

Cisplatin-induced nephropathy model
type: Class
subclass of: Tubular-toxicity model
comment: Cisplatin is an anti-tumor agent. It is absorbed and accumulated in the S3 segment of the proximal tubule, inducing apoptosis and necrosis of epithelial cells. Cisplatin-induced nephropathy is now considered to be more a generic model than a model mimicking the clinical situation as its use declines in clinic.

Axiom
annotated target: Cisplatin is an anti-tumor agent. It is absorbed and accumulated in the S3 segment of the proximal tubule, inducing apoptosis and necrosis of epithelial cells. Cisplatin-induced nephropathy is now considered to be more a generic model than a model mimicking the clinical situation as its use declines in clinic.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Cisplatin-induced nephropathy model
annotated property: comment

Mercuric chloride-induced nephropathy model
type: Class
subclass of: Tubular-toxicity model

Gentamicin-induced nephropathy model
type: Class
subclass of: Tubular-toxicity model
comment: Gentaminin is a aminoglycoside antibiotic. Proximal tubule concentrate aminoglycoside, inducing mitochondrial and lysosomal dysfunction. This model is highly relevant clinically. It displays myeloid bodies in proximal cells as it is observed in humans.

Axiom
annotated target: Gentaminin is a aminoglycoside antibiotic. Proximal tubule concentrate aminoglycoside, inducing mitochondrial and lysosomal dysfunction. This model is highly relevant clinically. It displays myeloid bodies in proximal cells as it is observed in humans.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Gentamicin-induced nephropathy model
annotated property: comment

Folic acid-induced nephropathy model
type: Class
subclass of: Tubular-toxicity model

Ciclosporin-induced nephropathy model
type: Class
subclass of: Tubular-toxicity model
subclass of: Immunosuppressor-induced nephropathy model

Immune-mediated model
type: Class
subclass of: Agent-induced model

Glomerulonephritis model
type: Class
subclass of: KUPO_0000005
subclass of: Restriction
  on property: mimics
  some values from: DOID 2921

Mesangioproliferative glomerulonephritis model
type: Class
subclass of: Glomerulonephritis model
subclass of: Restriction
  on property: mimics
  some values from: DOID 4783
alternative label: Mesangial proliferative glomerulonephritis model
alternative label: MsPGN

Axiom
annotated target: MsPGN
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Mesangioproliferative glomerulonephritis model
annotated property: altLabel

Axiom
annotated target: Mesangial proliferative glomerulonephritis model
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Mesangioproliferative glomerulonephritis model
annotated property: altLabel

Thy-1 nephritis model
type: Class
subclass of: Immune-mediated model
subclass of: Mesangioproliferative glomerulonephritis model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100004
subclass of: Restriction
  on property: mimics
  some values from: DOID 2986
subclass of: Restriction
  on property: mimics
  some values from: DOID 4783
subclass of: Restriction
  on property: mimics
  some values from: DOID 1312
alternative label: Anti-Thy 1.1 glomerulonephritis
alternative label: Anti-Thy 1.1 nephritis
alternative label: Anti-Thy-1 glomerulonephritis
alternative label: Anti-Thy-1 nephritis
comment: Thy-1 (THYmocyte differentiation antigen 1), also known as CD90, is a 25-37 kDa cell surface protein originally found to be expressed on thymocytes.

Axiom
annotated target: Anti-Thy 1.1 nephritis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis model
annotated property: altLabel

Axiom
annotated target: Anti-Thy 1.1 glomerulonephritis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis model
annotated property: altLabel

Axiom
annotated target: Anti-Thy-1 nephritis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis model
annotated property: altLabel

Axiom
annotated target: Thy-1 (THYmocyte differentiation antigen 1), also known as CD90, is a 25-37 kDa cell surface protein originally found to be expressed on thymocytes.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis model
annotated property: comment

Axiom
annotated target: Anti-Thy-1 glomerulonephritis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis model
annotated property: altLabel

Thy-1 nephritis rat model
type: Class
subclass of: Thy-1 nephritis model
comment: Rats express the Thy-1.1 antigen on mesangial cells. To induce Thy-1 nephritis, rats are injected with a rabbit anti-thymocyte serum (ATS) or a mouse anti-Thy 1 mAB (e.g. OX-7 or 1-22-3). Thy-1 nephritis is characterized by initial mesangolysis, followed by mesangial proliferation and mesangial matrix expansion, similar to that seen in human variants of mesangial proliferative glomerulonephritis. However, in the rat model w/o uninephrectomy, mesangial proliferation is transient and spontaneous regeneration occurs (reversible model).

Axiom
annotated target: Rats express the Thy-1.1 antigen on mesangial cells. To induce Thy-1 nephritis, rats are injected with a rabbit anti-thymocyte serum (ATS) or a mouse anti-Thy 1 mAB (e.g. OX-7 or 1-22-3). Thy-1 nephritis is characterized by initial mesangolysis, followed by mesangial proliferation and mesangial matrix expansion, similar to that seen in human variants of mesangial proliferative glomerulonephritis. However, in the rat model w/o uninephrectomy, mesangial proliferation is transient and spontaneous regeneration occurs (reversible model).
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis rat model
annotated property: comment

Thy-1 nephritis rat model associated with uninephrectomy
type: Class
subclass of: Surgical model
subclass of: Thy-1 nephritis model
comment: Rats express the Thy-1.1 antigen on mesangial cells. To induce Thy-1 nephritis, rats are injected with a rabbit anti-thymocyte serum (ATS) or a mouse anti-Thy 1 mAB (e.g. OX-7 or 1-22-3). Thy-1 nephritis is characterized by initial mesangolysis, followed by mesangial proliferation and mesangial matrix expansion, similar to that seen in human variants of mesangial proliferative glomerulonephritis. In the rat model associated with uninephrectomy, progressive development of glomerulosclerosis occurs (irreversible model), perharps mimicking more closely what happen during mesangial proliferative glomerulonephritis in humans.

Axiom
annotated target: Rats express the Thy-1.1 antigen on mesangial cells. To induce Thy-1 nephritis, rats are injected with a rabbit anti-thymocyte serum (ATS) or a mouse anti-Thy 1 mAB (e.g. OX-7 or 1-22-3). Thy-1 nephritis is characterized by initial mesangolysis, followed by mesangial proliferation and mesangial matrix expansion, similar to that seen in human variants of mesangial proliferative glomerulonephritis. In the rat model associated with uninephrectomy, progressive development of glomerulosclerosis occurs (irreversible model), perharps mimicking more closely what happen during mesangial proliferative glomerulonephritis in humans.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis rat model associated with uninephrectomy
annotated property: comment

Thy-1 nephritis mouse model
type: Class
subclass of: Transgenic model
subclass of: Thy-1 nephritis model
comment: Normal mice do not express the Thy-1.1 antigen in the kidney. For this reason, transgenic mice that ectopically express a mice-human chimeric Thy-1.1 antigen on podocytes have been developed. These mice slowly and spontaneously develop albuminuria and focal segmental glomerulosclerosis (FSGS). Injection of mAb directed against the Thy-1.1 antigen or against aminopeptidase (APA, an enzyme expressed in proximal tubule epithelial cells and podocytes), induces an acute albuminuria within 1 day and accelerate the development of FSGS lesions within 3 wk. FSGS lesions in this mouse model mimicks the collapsing variant of human FSGS.

Axiom
annotated target: Normal mice do not express the Thy-1.1 antigen in the kidney. For this reason, transgenic mice that ectopically express a mice-human chimeric Thy-1.1 antigen on podocytes have been developed. These mice slowly and spontaneously develop albuminuria and focal segmental glomerulosclerosis (FSGS). Injection of mAb directed against the Thy-1.1 antigen or against aminopeptidase (APA, an enzyme expressed in proximal tubule epithelial cells and podocytes), induces an acute albuminuria within 1 day and accelerate the development of FSGS lesions within 3 wk. FSGS lesions in this mouse model mimicks the collapsing variant of human FSGS.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Thy-1 nephritis mouse model
annotated property: comment

Anti-GBM nephritis model
type: Class
subclass of: KUPO_0000005
subclass of: Glomerulonephritis model

Habu snake venom model
type: Class
subclass of: Agent-induced model
subclass of: Mesangioproliferative glomerulonephritis model
alternative label: HSV glomerulonephritis
comment: Intravenous injection of HSV provokes acute focal mesangial proliferative glomerulonephritis in rodents.

Axiom
annotated target: HSV glomerulonephritis
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Habu snake venom model
annotated property: altLabel

Axiom
annotated target: Intravenous injection of HSV provokes acute focal mesangial proliferative glomerulonephritis in rodents.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Habu snake venom model
annotated property: comment

Membranoproliferative glomerulonephritis model
type: Class
subclass of: Glomerulonephritis model
alternative label: MPGN
comment: MPGN is characterized by glomerular hypercellularity, mesangial matrix expansion, thickening of the peripheral capillary walls, progressive loss of renal function eventually resulting in end-stage renal disease. Clinically, MPGN is characterized by proteinuria (up to nephrotic range), hypertension, and haematuria.

Axiom
annotated target: MPGN
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Membranoproliferative glomerulonephritis model
annotated property: altLabel

Axiom
annotated target: MPGN is characterized by glomerular hypercellularity, mesangial matrix expansion, thickening of the peripheral capillary walls, progressive loss of renal function eventually resulting in end-stage renal disease. Clinically, MPGN is characterized by proteinuria (up to nephrotic range), hypertension, and haematuria.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: Membranoproliferative glomerulonephritis model
annotated property: comment

CFH-deficiency model
type: Class
subclass of: Membranoproliferative glomerulonephritis model
alternative label: Cfh(-/-)
alternative label: Complement Factor H deficiency

Axiom
annotated target: Complement Factor H deficiency
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: CFH-deficiency model
annotated property: altLabel

Axiom
annotated target: Cfh(-/-)
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: CFH-deficiency model
annotated property: altLabel

CFH-deficiency mouse model
type: Class
subclass of: Knock-out model
subclass of: CFH-deficiency model
alternative label: CFH-deficient mouse
comment: MPGN II/DDD (dense deposit disease) similarities: mesangial hypercellularity, mesangial matrix expansion, capillary wall thickening and electron-dense deposits (C3 and C9) in the subendothelial space but not in the GBM. Cfh(-/-) mice also develop proteinuria, haematuria and die from renal failure.

Axiom
annotated target: CFH-deficient mouse
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: CFH-deficiency mouse model
annotated property: altLabel

Axiom
annotated target: MPGN II/DDD (dense deposit disease) similarities: mesangial hypercellularity, mesangial matrix expansion, capillary wall thickening and electron-dense deposits (C3 and C9) in the subendothelial space but not in the GBM. Cfh(-/-) mice also develop proteinuria, haematuria and die from renal failure.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: CFH-deficiency mouse model
annotated property: comment

CFH-deficiency piglet model
type: Class
subclass of: Knock-out model
subclass of: CFH-deficiency model
alternative label: CFH-deficient piglet
comment: MPGN II/DDD (dense deposit disease) phenotype: glomerular hypercellularity, mesangial matrix expansion, electron-dense material and C3 deposits within GBM. Animals die from renal failure.

Axiom
annotated target: MPGN II/DDD (dense deposit disease) phenotype: glomerular hypercellularity, mesangial matrix expansion, electron-dense material and C3 deposits within GBM. Animals die from renal failure.
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: CFH-deficiency piglet model
annotated property: comment

Axiom
annotated target: CFH-deficient piglet
created by: http://kupkb.org/populous#OPPL_pattern
annotated source: CFH-deficiency piglet model
annotated property: altLabel

Genetic in vitro model
type: Class
subclass of: KUPO_0000006

Agent-induced in vitro model
type: Class
subclass of: KUPO_0000006

Ciclosporine A in vitro model
type: Class
subclass of: Immunosuppressor in vitro model

High glucose in vitro model
type: Class
subclass of: Agent-induced in vitro model

Calcium oxalate monohydrate in vitro model
type: Class
subclass of: Agent-induced in vitro model
alternative label: Calcium oxalate crystals in vitro model
alternative label: COM in vitro model

Renal transplant rejection model
type: Class
subclass of: Surgical model
subclass of: Renal transplantation model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100007

Interstitial fibrosis and tubular atrophy model
type: Class
subclass of: Renal transplant rejection model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100006
alternative label: IF/TA model
alternative label: Chronic allograft nephropathy model
alternative label: CAN model

Acute renal allograft rejection model
type: Class
subclass of: Renal transplant rejection model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100005

Other animal model
type: Class
subclass of: KUPO_0000005

Other in vitro model
type: Class
subclass of: KUPO_0000006

Renal transplantation model
type: Class
subclass of: KUPO_0000005
subclass of: Surgical model

Allogenic transplantation model
type: Class
subclass of: Renal transplant rejection model
subclass of: Renal transplantation model

Syngenic transplantation model
type: Class
subclass of: Renal transplantation model

Interstitial fibrosis and tubular atrophy model (allogenic transplantation)
type: Class
subclass of: Interstitial fibrosis and tubular atrophy model
subclass of: Allogenic transplantation model

Acute renal allograft rejection model (allogenic transplantation)
type: Class
subclass of: Acute renal allograft rejection model
subclass of: Allogenic transplantation model

Hypoxia in vitro model
type: Class
subclass of: KUPO_0000006

Oxidative stress in vitro model
type: Class
subclass of: KUPO_0000006

H2O2 in vitro model
type: Class
subclass of: Agent-induced in vitro model
subclass of: Oxidative stress in vitro model

PDGF in vitro model
type: Class
subclass of: Agent-induced in vitro model

CTGF in vitro model
type: Class
subclass of: Agent-induced in vitro model

TGFbeta in vitro model
type: Class
subclass of: Agent-induced in vitro model

Immunosuppressor in vitro model
type: Class
subclass of: Agent-induced in vitro model

Sirolimus in vitro model
type: Class
subclass of: Immunosuppressor in vitro model

Tacrolimus in vitro model
type: Class
subclass of: Immunosuppressor in vitro model

Vasopressine in vitro model
type: Class
subclass of: Agent-induced in vitro model

Nephrotoxicant in vitro model
type: Class
subclass of: Agent-induced in vitro model

Cisplatin in vitro model
type: Class
subclass of: Nephrotoxicant in vitro model

Gentamicin in vitro model
type: Class
subclass of: Nephrotoxicant in vitro model

LPS induced in vitro model
type: Class
subclass of: Agent-induced in vitro model

LPS induced model
type: Class
subclass of: Agent-induced model

Immunosuppressor-induced nephropathy model
type: Class
subclass of: Nephrotoxic model

Cystic kidney disease model
type: Class
subclass of: KUPO_0000005
subclass of: Restriction
  on property: mimics
  some values from: DOID 2975

Polycystic kidney disease model
type: Class
subclass of: Cystic kidney disease model
subclass of: Restriction
  on property: mimics
  some values from: Polycystic kidney disease

AGE in vitro model
type: Class
subclass of: Agent-induced in vitro model

Lupus nephritis model
type: Class
subclass of: Glomerulonephritis model
subclass of: Restriction
  on property: mimics
  some values from: KUPO_0100020
comment: Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. About half of cases of SLE demonstrate signs of lupus nephritis at one time or another. Renal-specific signs include proteinuria (100%), nephrotic syndrome (55%), granular casts (30%), red cell casts (10%), microhematuria (80%), macrohematuria (2%), reduced renal function (60%), RPGN (30%), ARF (2%), hypertension (35%), hyperkalemia (15%) and tubular abnormalities (70%).

Aristolochic acid-nephrotoxic model
type: Class
subclass of: Tubular-toxicity model
subclass of: Restriction
  on property: mimics
  some values from: DOID 3052
comment: Aristolochic acids are a family of carcinogenic, mutagenic, and nephrotoxic compounds commonly found in the Aristolochiaceae family of plants, including Aristolochia and Asarum (wild ginger), which are commonly used in Chinese herbal medicine. Aristolochic acids are hypothesized to be causative agents in Balkan endemic nephropathy; and a related—possibly identical—condition known as "Chinese herbs nephropathy".

Develomental cigarette smoke-nephrotoxic model
type: Class
subclass of: Nephrotoxic model
comment: Foetal exposure to cigarette smoke during pregancy (developmental cigarette smoke exposure (CSE)) results in intrauterine growth retardation with a predisposition to obesity and cardiovascular disease at maturity.

Diffuse mesangial sclerosis model
type: Class
subclass of: Mesangioproliferative glomerulonephritis model
comment: The term diffuse mesangial sclerosis (DMS) indicates a characteristic glomerular histological alteration that occurs in childhood nephrotic syndrome and is associated with genetic alterations. Histopathological findings consist in glomeruli with mesangial expansion by increased mesangial matrix, with capillary walls that may be normal initially, but with hypertrophy and hyperplasia of podocytes. By advancing the process (usually in months or a few years), there is progressively greater mesangial expansion, capillary lumens are lost and the capillary walls are difficult to see clearly. In the terminal stages there is glomerular sclerosis.

Denys-drash syndrome model
type: Class
subclass of: Diffuse mesangial sclerosis model
subclass of: Restriction
  on property: mimics
  some values from: DOID 3764
comment: A rare congenital syndrome caused by mutations in the WT1 gene. Causes kidney failure before age 3, abnormal development of the sexual organs, and, in most cases, Wilms tumor (a type of kidney cancer). Children with Denys-Drash syndrome are also at high risk of some other types of cancer.

HIV-induced in vitro model
type: Class
subclass of: Agent-induced in vitro model
subclass of: Restriction
  on property: mimics
  some values from: DOID 1312
comment: HIV-associated nephropathy (HIVAN) refers to kidney disease developing in association with HIV infection. The most common, or "classical", type of HIV-associated nephropathy is a collapsing focal segmental glomerulosclerosis (FSGS), though other forms of kidney disease may also occur with HIV. HIVAN may be caused by direct infection of the renal cells with the HIV-1 virus, with resulting renal damage through the viral gene products. It could also be caused by changes in the release of cytokines during HIV infection.